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Category:Mixed-signal circuitsIntroduction {#s0001}
============

Successful graft-versus-host disease (GVHD) prophylaxis is a prerequisite for improved survival and quality of life in patients with haematological malignancies.[@cit0001] Reduced intensity conditioning regimens lead to increased incidence of GVHD, necessitating major steroids which can cause or worsen arterial thrombotic manifestations.[@cit0003]

Case Report {#s0002}
===========

A 31 year old male with B cell lymphoma underwent a matched unrelated donor transplant with reduced intensity conditioning (fludarabine, thiotepa and antithymocyte globulin) and peripheral blood stem cell (PBSC) graft.

A standard conditioning regimen and intravenous and oral Methotrexate (MTX) for prophylaxis of acute GVHD were administered. Aplastic anaemia prophylaxis consisted of cyclosporin and mycophenolate mofetil (MMF). Cyclosporin was discontinued on day +23 post-transplant with documented serum cyclosporine level of 9.9 ng/ml (35–50 ng/ml).

Post-transplant day +39, the patient developed grade 2 pruritus, erythematous macules and papules at the oral and proximal forearm skin and a ‘coffee bean’ papule overlying the right foot ([Fig. 1](#f0001){ref-type=”fig”}). Clobetasol propionate 0.05% lotion was applied to the right foot papule. Intravenous methylprednisolone was administered for 3 days followed by oral prednisone 1 mg/kg. MMF was discontinued due to asymptomatic hyperuricaemia (\>500 μmol/l). Further investigation revealed no fungal infection and abdominal ultrasound and computed tomography of the abdomen were normal. At 3 months post-transplant all skin lesions had resolved. Two years later no signs of chronic GVHD have been observed. Figure 1.Right foot papule overlying the centre of a large, painful cutaneous ulceration with erythematous borders.

Discussion {#s0003}
==========

Post-transplant immunosuppression-induced thrombotic thrombocytop http://mytown247.com/?p=40233

 

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