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Honestech Vhs To Dvd 3.0 SEUsefulness of P-Selectin Gene Polymorphisms for Predicting Cerebral Embolism in Patients With Mechanical Thrombectomy.
P-selectin gene polymorphism influences platelet adhesion and aggregation in human, and its polymorphism has an impact on platelet function and coronary thrombosis. However, the P-selectin gene polymorphism has not been studied in patients with acute ischemic stroke with or without mechanical thrombectomy. This study investigated whether P-selectin gene polymorphism would be associated with cerebral embolism (CE) and clinical outcome of acute ischemic stroke with or without thrombectomy. One hundred seventy-three consecutive patients with acute ischemic stroke who underwent mechanical thrombectomy were included in the study. The polymorphisms of P-selectin gene were analyzed for predicting CE. Genetic analysis of the P-selectin gene was performed in 159 (91.2%) patients, including 4 (2.5%) patients with the homozygous variant of Ser534Ser (S/S), 4 (2.5%) patients with the heterozygous variant of Ser534Thr (S/T), and 51 (30.5%) patients with the homozygous variant of Thr534Thr (T/T). We performed logistic regression analysis to identify the risk factor for CE, and the variables were adjusted by age, past medical history, and National Institutes of Health Stroke Scale score at admission. CE was observed in 14 (7.8%) patients. The risk factor for CE was the P-selectin T/T genotype (odds ratio, 6.76; 95% confidence interval, 1.34-34.79; P=0.021). The mortality rates were significantly higher in the T/T genotype compared to the S/S or S/T genotype (P=0.016). The P-selectin gene polymorphism might be a useful marker for predicting CE in patients with acute ischemic stroke who underwent thrombectomy.(CNN) — President Obama is tapping Joseph Rago, an expert on international environmental policy, to serve as the administration’s new chief of staff.

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